Ray Vanderby Jr., MS, PhD

Ray Vanderby Jr., MS, PhD

Professor
 
Office
5059 WIMR
1111 Highland Avenue
Madison, WI 53705
(608) 263-9593
 

Education

  • Bachelor of Science
    Purdue University, West Lafayette, IN, 1968
  • Master of Science
    Purdue University, West Lafayette, IN, 1972
  • PhD
    Purdue University, West Lafayette, IN, 1975
  • Postdoctoral Fellow
    University of Connecticut

Research Interests

Dr. Vanderby is a professor in the Biomedical Engineering Department and in the Orthopedics and Rehabilitation Department where he directs the Orthopedic Research Laboratories. He has an affiliate appointment in the Departments of Engineering Physics and Mechanical Engineering. His research focuses entirely on orthopedic issues.
 
Dr. Vanderby is particularly interested in orthopedic tissues (bone, ligament, tendon, cartilage, etc.). His research focuses on wound healing or regeneration of these tissues via tissue engineering. This includes equal parts of functional characterization (e.g. biomechanics), microstructural morphology and composition, and the relevant biological sciences (cell and molecular biology, histology, etc.).
 
Additionally, Dr. Vanderby is interested in ultrasonic wave propagation in these tissues for clinically relevant characterization, in knee reconstruction, in fracture fixation, and in the biomechanics of the spine. To study these orthopedic issues, he uses and adapts engineering and biological methods including experimental, analytical, and computational mechanics.

Active Grants

 

Modulation of the Immune System to Modulate Ligament/Ligament Graft Healing

Funding Source: National Institutes of Health 5R01AR059916-03
 
This project is to develop local methods of delivery to modulate immune response during ligament healing. The overall goal is to reduce fibrosis and increase regeneration in rat MCL and ACL models. This is done by modulation of various phenotypes of macrophages.
 

Congenic Mouse Strains Harboring Bone Strength Quantitative Trait Loci

Funding Source: National Institutes of Health 5R01AR054753-04 (PI: Blank)
 
This project is to Identifying genes that affect bone biomechanical performance and understanding their interactions. It uses recombinant congenic mice. My role is biomechanical testing of bones from these mice.
 

Bioadhesive Membrane Construct to Augment Tendon Repair

Funding Source: National Institutes of Health / Kensey Nash Corporation 5R44AR056519-03
 
The goal of this propsal is to explore bone regeneration at a fundamental level utilizing a mouse digit regeneration model to study the molecular mechanisms. Although digit regeneration is an established model, many aspects of true bone regeneration have yet to be elucidated. We propose to use genetic tools to specifically label the bone lineage, follow their fate, and carry out molecular profiling, identifying potential regenerative targets.
 

Osteoblast Fate And Cell Signaling During Bone Regeneration

Funding Source: AO Foundation S-13-170C (PI: Chamberlain)
 
The goal of this propsal is to explore bone regeneration at a fundamental level utilizing a mouse digit regeneration model to study the molecular mechanisms. Although digit regeneration is an established model, many aspects of true bone regeneration have yet to be elucidated. We propose to use genetic tools to specifically label the bone lineage, follow their fate, and carry out molecular profiling, identifying potential regenerative targets.
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