- Bachelor of Science
Purdue University, West Lafayette, IN, 1968
- Master of Science
Purdue University, West Lafayette, IN, 1972
Purdue University, West Lafayette, IN, 1975
- Postdoctoral Fellow
University of Connecticut
Dr. Vanderby is a professor in the Biomedical Engineering Department and in the Orthopedics and Rehabilitation Department where he directs the Orthopedic Research Laboratories. He has an affiliate appointment in the Departments of Engineering Physics and Mechanical Engineering. His research focuses entirely on orthopedic issues.
Dr. Vanderby is particularly interested in orthopedic tissues (bone, ligament, tendon, cartilage, etc.). His research focuses on wound healing or regeneration of these tissues via tissue engineering. This includes equal parts of functional characterization (e.g. biomechanics), microstructural morphology and composition, and the relevant biological sciences (cell and molecular biology, histology, etc.).
Additionally, Dr. Vanderby is interested in ultrasonic wave propagation in these tissues for clinically relevant characterization, in knee reconstruction, in fracture fixation, and in the biomechanics of the spine. To study these orthopedic issues, he uses and adapts engineering and biological methods including experimental, analytical, and computational mechanics.
Roles of Neutrophils and Macrophages in Recovery of Muscle Function Following Single Stretch Injury In Mice
Funding Source: Medical School Research Committee Grant
This proposed research will seek to establish the roles of neutrophils and subtypes of macrophages in muscle regeneration following a controlled stretch injury to the calf muscle in mice. This research will provide information about the cell types and inflammatory mediators required for successful repair and regeneration as well as fibrosis. This will provide the framework for future mechanistic studies using knock-in and knock-out genetically engineered mice to modulate the inflammatory response to stretch injury.
Modulation of the Immune System to Modulate Ligament/Ligament Graft Healing
Funding Source: National Institute of Health 1R21 EB08548
This grant is to develop more regenerative healing in ligaments and tendons, rather than fibrotic healing that now occurs. By modulating the inflammatory response of the immune system, we are minimizing the size of the scar tissue formed after injury and we are creating an extracellular matrix that is more consistent with the native tissue (e.g. collagen I rather than collagen III). The study uses rat models for MCL and ACL injuries and modulates the immune system with locally and temporally controlled exogenous factors.
Controlled Delivery of Biologics to Improve Tendon to Bone Healing
Funding Source: Coulter Translational Partnerships
Injury and repair. Biomechanically evaluate outcome non-invasively over healing with ultrasound methods and mechanically at terminal points in the experiment. Ray Vanderby's role is to biomechanically evaluate outcome non-invasively over healing with ultrasound methods and mechanically at terminal points in the experiment.
Noninvasive Measurement of Strain and Mechanical Properties in Tendons/Ligaments
Funding Source: National Institute of Health 1R21 EB08548
This grant is developing a new method of ultrasound wave analysis in order to non-invasively compute mechanical properties & functional strains in ligaments & tendons. It also considers this method as a way to distinguish and identify breast cancer tumors. For ligaments and tendons, in vitro and in situ porcine models are being used with A-mode ultrasound signals. For mammary tumors, mouse models are used. This does not utilize the improved method of tracking that is proposed for B-mode signals. This grant does not create localized pathologies and methods used in this grant are not capable of adequately tracking localized tendinopathies.
Congenic Mouse Strains Harboring Bone Strength Quantitative Trait Loci
Funding Source: National Institute of Health 1R01 AR054753
This study is to determine genetic loci and their role in bone fragility. Various congenic mice will have their long bones studied for morphology and strength. Ray Vanderby's role is a co-investigator to set up, supervise, and interpret all mechanical bone testing.
Viscoelasticity and Damage of Ligament: Loading and Recovery
Funding Source: National Science Foundation CMS 0553016
This grant is to develop new analytical models to quantify viscoelastic behavior of normal and damaged ligaments during loading & unloading based on in vitro testing. A goal is to quantify tissue damage and post-damage behavior. The ultimate goal is to provide a method of quantification that can be used after ligament/tendon injury to evaluate the risk of further damage and to evaluate efficacy of various therapeutic methods via viscoelastic models.
Biocomputation of the Links between Muscle Morphology, Coordination, and Injury
Funding Source: National Institute of Health R01 AR056201-02S
As a co-Investigator, Ray Vanderby's role is to use ultrasound methods to quantify mechanical tissue behavior at the musculotendon junction.
An Ultrasound Method to Measure the Load Bearing Function of Tendons and Ligaments
Funding Source: IEDR, Graduate School, UW-Madison
The overall goal of this study is to partner with a local company (Echometrix, LLC) and develop an interoperative ultrasound probe and method to estimate the load bearing function of ligaments and tendons during surgery.
Acoustoelastography as an Outcome Measure for Platelet-Rich Plasma Injection Treatment of Chronic Plantar Fasciitis: A Pilot Study
Funding Source: RSNA Research & Education Foundation
The overall goals of the study are to determine the clinical efficacy of PRP treatment in human plantar faciitis and to show that acoustoelasticity, a new technique for the analysis of ultrasound waves, can quantify treatment effects. Ray Vanderby's role as a co-investigator is to support ultrasound analyses with methods developed in his lab.
Bioadhesive Membrane Construct to Augment Tendon Repair
Funding Source: National Institute of Health 2R44AR056519-02; SBIR for Nerites Corp.
The overall goal of this SBIR is to develop a novel bioadhesive wrap to secure torn ends of Achilles tendons in an ovine model while they heal. Ray Vanderby is PI for the subcontract to UW. The subcontract will perform sheep surgeries and test the outcomes histologically and mechanically. Nerites will develop and supply the Bioadhesive wraps. There is no biological augmentation to healing in this study. It only tests this system to hold the torn tendon ends together better than sutures.