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William L. Murphy, MS, PhD
Associate Professor
Office
5009 WIMR
1111 Highland Drive
Madison, WI 53705
(608) 265-9918
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Education
- Bachelor of Science
Wesleyan University, Bloomington, IL, 1998
- Master of Science
University of Michigan, Ann Arbor, MI, 2000
- PhD
University of Michigan, Ann Arbor, MI, 2002
- Postdoctoral Fellow
University of Chicago, IL, 2002-2004
Research Interests
Dr. Murphy's fields of interest and practice include creation of new biomaterials using bioinspired approaches, using biomaterials to define the stem cell microenvironment, the development of biomaterials for tissue regeneration (tissue engineering) and new approaches for drug delivery and gene therapy.
Active Grants
Roles of Neutrophils and Macrophages in Recovery of Muscle Function Following Single Stretch Injury In Mice
Funding Source: Medical School Research Committee Grant
This proposed research will seek to establish the roles of neutrophils and subtypes of macrophages in muscle regeneration following a controlled stretch injury to the calf muscle in mice. This research will provide information about the cell types and inflammatory mediators required for successful repair and regeneration as well as fibrosis. This will provide the framework for future mechanistic studies using knock-in and knock-out genetically engineered mice to modulate the inflammatory response to stretch injury.
Modulation of the Immune System to Modulate Ligament/Ligament Graft Healing
Funding Source: National Institute of Health 1R21 EB08548
This grant is to develop more regenerative healing in ligaments and tendons, rather than fibrotic healing that now occurs. By modulating the inflammatory response of the immune system, we are minimizing the size of the scar tissue formed after injury and we are creating an extracellular matrix that is more consistent with the native tissue (e.g. collagen I rather than collagen III). The study uses rat models for MCL and ACL injuries and modulates the immune system with locally and temporally controlled exogenous factors.
Controlled Delivery of Biologics to Improve Tendon to Bone Healing
Funding Source: Coulter Translational Partnerships
Injury and repair. Biomechanically evaluate outcome non-invasively over healing with ultrasound methods and mechanically at terminal points in the experiment. Ray Vanderby's role is to biomechanically evaluate outcome non-invasively over healing with ultrasound methods and mechanically at terminal points in the experiment.
Controlling Soluable Morphogen Gradients in Biomaterials
Funding Source: National Science Foundation, UW Stem Cell and Regenerative Medicine Center
Biologically Active Sutures for Orthopedic Tissue Healing
Funding Source: Wallace H. Coulter Foundation
Bio-Responsive Materials Based on Engineered Motor Proteins
Funding Source: National Science Foundation
Ideal Substitutes for Healing Large Bone Defects
Funding Source: AO Research Foundation
Towards a Synthetic Basement Membrane for the Corneal Epithelium
Funding Source: National Institute of Health (R01)
Biomaterials for Local Regulation of Growth Factor Signaling
Funding Source: National Institute of Health (R01)
Surface Engineering Strategies for Studying Human MSCs
Funding Source: National Science Foundation
Silicate Bioceramic Structure and Texture Control on Activating Osteoblast Proliferation and Differentiation
Funding Source: National Science Foundation
Microsphere-mediated Differentiation of Embryonic Stem Cells
Funding Source: National Institute of Health (R01)
Collaborative Research: Regulators of Cellular Microenvironment and Multiscale Osteointegration
Funding Source: National Science Foundation
Enhanced Vascularized Bone Regeneration
Funding Source: AO Foundation
Linkage of Orthobiologics to the Scaffold Platform to Promote Large Bone Defect Healing
Funding Source: AO Foundation
Tendon Repair Using Cytokine Coated Surgical Sutures in a Rabbit Partial Achilles Tendon Laceration
Funding Source: AO Foundation