The University of Wisconsin is a satellite research center of the Major Extremity Trauma Research Consortium (METRC), an initiative funded by the Department of Defense. We are currently involved in four clinical trials investigating patient outcomes following high-energy orthopedic injuries. These multi-center trials are designed to generate high-quality evidence that will help establish optimal treatment protocols and improve outcomes for both civilian and military patients who sustain major trauma to the extremities.
The studies we’re involved in:
This study will see what medicine is better to use for preventing death and clinically important blood clots in the lungs in patients who sustain trauma. There are two types of medicine we will compare in this study: Low Molecular Weight Heparin (Lovenox/Enoxaparin) and Aspirin. Our goal is to find the simplest, most effective medication for orthopedic trauma patients.
The goal of this study is to investigate the efficacy of oral antibiotic therapy versus intravenous systemic antibiotics in the treatment of acute infection after plate fixation of fractures.
The primary objective of this study is to compare levels of impairment and functional outcomes for patients undergoing a transtibial amputation and randomized to receive an endbearing tibia-fibula synostosis (Ertl procedure) versus a standard posterior flap procedure (Burgess procedure)
This study will assess the efficacy of supplemental perioperative oxygen in the prevention of surgical site infections.
This study will compare two standard options for treating severe open tibia fractures internal fixation with a nail or plate and external ring fixation.
The primary objective of this study is to compare the proportion of deep surgical site infections within 6 months in patients treated with local Vancomycin powders compared to those treated without local Vancomycin powder.
This study will examine the reliability, validity and responsiveness of the PROMIS tools for clinical research following orthopedic trauma.
Faculty involved in these studies
- Paul Whiting (local PI on PREVENT CLOT, OXYGEN, POVIV, TAOS; Study Surgeon)
- Christopher Doro (local PI on VANCO, FIXIT, STREAM; Study Surgeon)
- David Goodspeed (Study Surgeon)
- Gerald Lang (Study Surgeon)
- Christopher Domes (Study Surgeon)
Published Articles on METRC:
Major Extremity Trauma Research Consortium (METRC). Building a clinical research network in trauma orthopaedics: the Major Extremity Trauma Research Consortium (METRC). J Orthop Trauma. 2016;30(7):353–61. doi:10.1097/bot. 0000000000000549PubMed
Castillo RC, Mackenzie EJ, Bosse MJ, METRC Investigators. Measurement of functional outcomes in Major Extremity Trauma Research Consortium (METRC). J Am Acad Orthop Surg. 2012;20:S59-63. doi: 10.5435/JAAOS-20-08-S59. PubMed
Manson TT, Reider L, O’Toole RV, Scharfstein DO, Tornetta P 3rd, Gary JL; Major Extremity Trauma Research Consortium (METRC). Variation in treatment of displaced geriatric acetabular fractures among 15 Level-I Trauma Centers. J Orthop Trauma/ 2016;30:457-62. doi: 10.1097/BOT.0000000000000632. PubMed