Matthew W. Squire, MD, MS

Dr. Squire is an internationally known UW Health Joint Replacement Surgeon. He has performed over 6,000 joint replacement surgeries since starting his orthopedic practice in 2004. In the last 5 years he has performed 3,000 hip and knee replacement surgeries, one of the highest volumes in the Midwest. He is Fellowship Trained and performed his Hip and Knee Replacement training at the highly competitive and #1 ranked Hip and Knee Replacement Specialty Training Center known as OrthoCarolina. Graduates of the OrthoCarolina training center are known for their advanced knowledge of Hip and Knee Replacement Surgery, cutting-edge high impact research, and excellent surgical skills. His time at OrthoCarolina training center laid the foundation for Dr. Squire’s current surgical practice by exposing him to the most advanced surgical technology and minimally invasive Hip and Knee Replacement techniques which he has utilized and refined over the last 15 years.

Dr. Squire has over his career demonstrated an unparalleled track record of Hip and Knee Replacement success. He is recognized as a “destination surgeon” who treats patients traveling from all U.S. regions including Alaska and Hawaii as well as patients from other countries. His extremely low complication and readmission rates, as well as his excellent patient satisfaction scores have been instrumental in helping UW Health Hospitals achieve U.S. News and World Report’s top ranked Wisconsin Hospital status and UW Health’s Orthopedic Surgery Department top 20 ranking. Additionally, his surgical quality metrics were a key part in UW Health Hospital and Clinics obtaining Medicare’s highest performance ranking (excellent-top 2%) for total joint replacement care.

Throughout his practice, Dr. Squire has been a proud member of the American Association of Hip and Knee Surgeons, American Academy of Orthopedic Surgeons, International Consortium for Prosthetic Joint Infection, as well as the Arthritis Foundation. In conjunction with these organizations, Dr. Squire has been instrumental in developing “Best Practice” guidelines for hip and knee replacement surgeries. By following the “Best Practice” guidelines of these organizations, Dr. Squire has been able to obtain the greatest possible results and success for his joint replacement patients.

Dr. Squire is currently the Medical Director of the Wisconsin Arthritis Foundation. As Medical Director, Dr. Squire intimately understands how hip and knee arthritis negatively impacts personal health, well-being, and quality of life. Dr. Squire is committed to expanding educational and treatment outreach to patients living with arthritis so that they may move and live without pain. As a Hip and Knee Replacement surgeon and Arthritis Foundation Medical Director, he sees every day how Hip and Knee Joint Replacement can remarkably improve the quality of life for patients who suffer from arthritis.

Dr. Squire holds a Master’s Degree in Biomedical Engineering, which gives him unique knowledge and insight as he performs stem cell and cartilage research as well as designs joint replacement implants and bone cement products. His research has been published in many international journals. He is the co-designer of an internationally distributed hip replacement implant system and has multiple shared implant design patents. He is Co-Director of the UW Health Joint Replacement Program where his primary duty is to ensure the highest possible quality of joint replacements performed at UW Health Hospitals. He is a member of the UW Health Surgical Site Infection Committee, using his expertise to help ensure the safest possible operating room environment for all UW Health patients. He served as the UW Health Orthopedic Program Director for seven years and twice has been awarded Orthopedic Surgery Resident Educator of the Year.

Clinical Specialties

Dr. Squire specializes in surgical care of the hip and knee. His surgical practice is evenly split between hip and knee disorders. Dr. Squire routinely performs surgical care for young active patients (16 and older) as well as older patients. Dr. Squire’s hip practice includes surgical care of hip labral injuries, femoral acetabular impingement, sports related hip injuries, non-arthritic adolescent and adult hip pain, hip arthritis, and failed hip replacements. The most common hip surgeries he performs are hip arthroscopy, open surgical hip dislocation, minimally invasive and anterior hip replacement, and revision (re-do) hip replacement surgery. Dr. Squire’s knee practice includes surgical care of adult knee pain, knee arthritis, and failed knee replacements. The most common knee surgeries he performs are knee replacement, partial knee replacement, and revision (re-do) knee replacement surgery.

Professional Activities
  • Program Director, Orthopedic Surgery Residency Program, University of Wisconsin Department of Orthopedics, 2008-2015
  • Graduate Medical Education and Oversight Committee, University of Wisconsin Hospitals and Clinics, 2013-2015
  • Associate Member, American Association of Hip and Knee Surgeons, 2007-present
  • American Academy of Orthopedic Surgeons, 2007-present
  • Orthopedic Surgery Education Committee
  • Joint Subspecialty Planning Committee
  • Perioperative Medical Management Committee
  • Medical Director, Wisconsin Chapter of the Arthritis Foundation 2017-present
Research Interests
  • Hip and Knee Replacement Implant Design
  • Non-Destructive Implant Removal
  • Antibiotics and Bone Cement
  • Patient Outcomes Following Hip and Knee Surgery
  • Infection Prevention and Treatment for Hip and Knee Replacement Surgery
  • Stem cells and cartilage restoration
  • Hip Resurfacing
  • Obesity and Osteoarthritis
  • Avascular Necrosis
Board Certification
  • American Board of Orthopedic Surgery
Clinical Resources

Visit for patient resources on hip replacement or knee replacement surgery, including:

  • How to decide if you need a joint replacement
  • Setting expectations
  • Resources to supplement discussions with your surgeon
  • Videos
  • Living with a new joint replacement

UW Health at The American Center

Phone: (608) 263-7540

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Administrative Assistant
Carolyn Morris