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UW Research Team led by Wan-Ju Li, PhD, Awarded $500K Grant for Innovative Osteoarthritis Research


Earlier this month, Wan-Ju Li, PhD, associate professor in the UW Department of Orthopedics and Rehabilitation, and his research team were awarded a $500,000 Research Forward grant to support a bold new project that integrates cutting-edge science and engineering to tackle one of the biggest challenges in healthcare – osteoarthritis.

Affecting over 32 million Americans, osteoarthritis is a leading cause of chronic pain and disability, with current treatments providing only limited long-term relief. Although joint replacement surgery can restore function, the procedure involves the removal of damaged cartilage and bone and the replacement of these tissues with metal and plastic implants. This approach is highly invasive, costly, and may come with risks such as infection, implant failure, and lengthy recovery periods.

Dr. Li and his team are developing a novel, minimally invasive method to treat joint damage by bioprinting engineered cartilage directly inside the body.

The project brings together a multidisciplinary team of experts across medicine and engineering:

Principal Investigator

  • Dr. Wan-ju Li (Orthopedics) – Leads research in musculoskeletal tissue engineering and animal models for joint disease.

Co-Principal Investigators

  • Dr. Xiao Kuang (Mechanical Engineering) – Specializes in ultrasound-based 3D printing, biomaterials, and machine learning.
  • Dr. Chu Ma (Electrical and Computer Engineering) – Brings expertise in ultrasound imaging and real-time computational systems.
  • Dr. Andrea Spiker (Orthopedics) – Orthopedic surgeon providing critical clinical insight into joint injury and repair.

Together, the team is pioneering a first-of-its-kind technique that uses advanced ultrasound technology, custom-engineered bioinks, and AI-guided 3D printing to regenerate cartilage directly within the body, eliminating the need for open surgery. Unlike conventional surgical interventions that require large incisions and permanent synthetic implants, this new method uses ultrasound imaging to precisely guide the real-time printing of living cartilage directly inside the body, without the need for open surgery.

With the potential to dramatically reduce recovery time, surgical risks, and long-term complications, this safer, more targeted approach offers new hope to millions suffering from joint degeneration.


“Securing this highly competitive grant is a true testament to Dr. Li and his team, representing both visionary thinking and scientific excellence. By pioneering a method to print living cartilage inside the body using ultrasound guidance – without open surgery – this research promises to redefine orthopedic care and help millions suffering from joint degeneration.”

Bryan Heiderscheit, PT, PhD
Frederick Gaesnlen Professor in Orthopedics
Vice Chair of Research
Department of Orthopedics and Rehabilitation
University of Wisconsin School of Medicine and Public Health


About the Research Forward Initiative

Hosted by the UW-Madison Office of the Vice Chancellor for Research (OVCR) and funded by the Wisconsin Alumni Research Foundation (WARF), the Research Forward Initiative seeks to “stimulate and support highly innovative and groundbreaking research at the University of Wisconsin–Madison,” encouraging multidisciplinary, multi-investigator projects with the potential to transform fields and address major societal challenges.

Dr. Wan-Ju Li named Fellow of International Orthopaedic Research by ICORS


Wan-Ju Li, PhD, an associate professor in the UW Department of Orthopedics and Rehabilitation, has been inducted as a fellow of the International Combined Orthopaedic Research Societies (ICORS) – a prestigious recognition awarded to leading researchers who have made exceptional contributions to the field of orthopedic science.

As part of this honor, Dr. Li will hold the distinguished title of “Fellow of International Orthopaedic Research (FIOR),” recognizing his influential work in musculoskeletal tissue engineering, regenerative medicine, and translational research aimed at improving treatment for joint diseases such as osteoarthritis.

ICORS represents a global coalition of orthopedic research societies, and its fellowship program celebrates sustained excellence, leadership, and innovation in orthopedic research. Being named a FIOR marks an international acknowledgment of Dr. Li’s impact on the field and his dedication to advancing therapies that restore mobility and improve quality of life.

Dr. Li leads a multidisciplinary research program that bridges engineering, biology, and medicine and holds an affiliate appointment in the UW Department of Biomedical Engineering. His work includes pioneering techniques to regrow cartilage using ultrasound-guided 3D printing and bioengineered “sono-inks,” supported by a recently awarded $500K Research Forward grant.

Expressing his gratitude, Dr. Li said that the Department of Orthopedics and Rehabilitation has “helped shape [his] career and research program,” adding that “this recognition is something we share, and it wouldn’t have been possible without the backing and encouragement I have received here.”

Dr. Li will be formally inducted as a Fellow during a ceremony at the ICORS 2025 meeting in Adelaide, Australia, this October.


About ICORS

The International Combined Orthopaedic Research Societies (ICORS) serves as an alliance of societies to promote basic, translational, and clinical musculoskeletal research worldwide.

Dr. Andrea Spiker named Dr. William G. Clancy Jr. Professor in Sports Medicine


Andrea Spiker, MD, a nationally recognized leader in orthopedic surgery and sports medicine, has been appointed the inaugural Dr. William G. Clancy Jr. Professor in Sports Medicine in the Department of Orthopedics and Rehabilitation at the University of Wisconsin School of Medicine and Public Health (SMPH). This endowed professorship honors Dr. Spiker’s outstanding leadership, clinical innovation, and research contributions to the field of orthopedics.

She was formally recognized during the 2025 UW School of Medicine and Public Health Faculty Investiture Celebration on June 18, 2025. The event brought together more than 150 colleagues, supporters, and academic leaders to honor prestigious faculty and recognize the generous individuals who help make their pioneering work possible.

L-R: David Walsh (President of the Shapiro Foundation), Andrea Spiker, MD, William Clancy, MD, Tamara Scerpella, MD

An assistant professor in the Department of Orthopedics and Rehabilitation, Dr. Spiker is a board-certified orthopedic surgeon with dual fellowship training in sports medicine and hip preservation. She serves as a team physician for Badger Athletics and is the head orthopedic surgeon for the UW Men’s Basketball team. She is the founder and director of the UW Health Hip Preservation Program – the only comprehensive program of its kind in Wisconsin.

Her clinical expertise includes the diagnosis, treatment, and prevention of athletic injuries, with a focus on minimally invasive hip and knee procedures and hip preservation techniques. Nationally, Dr. Spiker is recognized for her work in hip arthroscopy and the management of complex sports injuries. She is a frequent invited speaker, an active contributor to clinical guidelines, and has authored 55 peer-reviewed publications – serving as first or senior author on 36.

Her current research focuses on patient-reported outcomes, hip biomechanics, and the evolution of pre-arthritic hip conditions. She serves as the site Principal Investigator for two Academic Network of Conservational Hip Outcome Research grants and was recently awarded a grant from the Arthroscopy Association of North America to study persistent post-hip arthroscopy pain using advanced imaging.

Beyond her clinical and research accomplishments, Dr. Spiker is a dedicated educator. She directs the Orthopedic Sports Medicine Fellowship, which will expand to include a second fellow in 2026, and mentors medical students through SMPH’s Shapiro Research Program. She is a recipient of both the SMPH Dean’s Award for Excellence in Medical Student Research Mentorship and the Arthroscopy Association of North America (AANA) Stephen J. Snyder Excellence in Teaching Award for her dedication in teaching hip arthroscopic surgical techniques to fellow AANA surgeons.

“Dr. Spiker demonstrates excellence and innovation in her clinical practice and scholarly activity, and she continually goes above and beyond the norm in service, mentorship, and teaching in our field,” said Dr. Tamara Scerpella, the Dr. Andrew A. McBeath Professor and Chair of the UW Department of Orthopedics and Rehabilitation.

The Dr. William G. Clancy Jr. Professorship in Sports Medicine – made possible through the generous support of the Herman and Gwen Shapiro Foundation and more than 110 individual donors – honors Dr. William Clancy, a pioneer in sports medicine whose groundbreaking work at UW-Madison laid the foundation for advancements in orthopedic surgery and athlete care worldwide. Dr. Spiker’s appointment carries forward his legacy of innovation and excellence in the field.

Congratulations to Dr. Spiker on this well-deserved recognition.

Kristyn Hare, PA, receives ISCD Clinician of the Year Award


The International Society for Clinical Densiometry (ISCD) presented Kristyn Hare, PA, with the 2024 ISCD Clinician of the Year Award. This honor is given to “an outstanding clinician for distinguished service to the field of densitometry in the areas of publication, education or leadership.” Kristyn received this award last month at the ISCD Annual Conference on Skeletal Assessment in Boston, MA. One of our outstanding physician assistants and a clinical densitometrist, Kristyn has a special interest in bone health and the treatment of osteoporosis.

 

Reflecting on 2024 – and plans for the year ahead


Tamara Scerpella, MD
AA McBeath Distinguished Professor | Chair, Department of Orthopedics & Rehabilitation | Chief, Division of Sports Medicine
University of Wisconsin School of Medicine and Public Health
.

As I reflect on the collective accomplishments of our department over the past year, I am struck by the progress we have made toward our shared vision to build excellence and distinction in clinical outcomes, translatable research, and graduate training programs that result in local, regional and national prominence. I am incredibly proud of our team’s commitment to advancing orthopedic surgery and rehabilitative medicine, and I am excited to share highlights of our department members’ numerous achievements during 2024 – as well as a glimpse of what to look forward to in 2025.


Clinical Excellence

We welcomed nine of the best and brightest physician specialists to our team in 2024. These additions bring our total faculty to 42 orthopedic and 14 rehabilitation medicine specialists, preparing us to meet the ever-growing needs of our patients in Dane County, Wisconsin, and the region as we enter 2025. We will continue to recruit surgeons, non-operative orthopedic specialists, pain medicine proceduralists and inpatient rehabilitation specialists over the coming year.

Our faculty contribute to the excellent patient care provided at a number of locations, including UW Health’s University Hospital, consistently ranked as the #1 hospital in Wisconsin and among the top 50 hospitals in the United States for orthopedic care by U.S. News & World Report. The UW Health Rehabilitation Hospital, where our faculty oversee the care of post-acute accident, stroke, burn, and other injuries, was ranked in the top ten percent of rehabilitation hospitals nationwide by healthcare software company Netsmart Technologies. These accolades reflect both our affiliated hospitals’ exceptional patient care and the skill and dedication of our department’s faculty physicians, advanced practice providers and resident trainees.

Innovative Research Initiatives

Our faculty researchers remain at the forefront of groundbreaking research in stem cell and regenerative medicine, sports-related concussion management, tendon healing, joint biomechanics, and more. With over 9,000 square feet of state-of-the-art research facilities, including the Orthopedic Research Laboratories and Badger Athletic Performance Labs, our researchers are developing innovative treatments to improve patient outcomes.

Key research highlights from 2024 include receiving a five-year NIH RO1 grant awarded to UW orthopedic surgeon Kenneth Noonan, MD, and Chris Brace, PhD, to develop a novel treatment for pediatric limb-length discrepancy (LLD). Their research holds the potential to transform the treatment of LLD in children by providing an exciting alternative to traditional surgical procedures that would improve the lives of young patients with this challenging medical condition.

Our Badger Athletic Performance (BAP) program, led by Bryan Heiderscheit, PT, PhD, continues to enhance the performance, safety and recovery of more than 800 Badger athletes. In addition, BAP has partnered with the NBA to study patellar tendon injury and the NFL to study hamstring injury and sport-related concussion. Applying knowledge gained through over a decade of BAP research, Dr. Heiderscheit’s innovative and effective approach to musculoskeletal injury prevention and recovery has drawn the attention of professional teams from across the globe and in our own backyard – as consultant to the Green Bay Packers and the Milwaukee Bucks. While professional athletes travel to BAP for individual consultation, testing and training protocols developed at BAP are implemented in training centers across the country.

We were thrilled when UW Orthopedics and Rehabilitation scientist Timothy McGuine, PhD – nationally recognized for his contributions to sports medicine research – was named the recipient of the 2024 Chancellor’s Award for Excellence in Research: Independent Investigator. I am grateful for Tim’s decades-long practical and translatable contributions to sports medicine research and can think of no one more deserving of this honor.

We look forward to many research developments in 2025 – among them is the launch of Forward Ortho, an innovative program led by William Murphy, PhD, focused on transforming novel orthopedic technologies into groundbreaking start-up companies that will accelerate healthcare solutions.

Education Highlights

We have a strong reputation for training well-rounded clinicians through comprehensive residency and fellowship programs. With a history spanning over 65 years, the Department has successfully trained numerous physicians who have become leaders in their respective fields. We plan an expansion of both Orthopedic Surgery and Rehabilitation Medicine residency training programs this year – bringing the orthopedic surgery complement to seven residents each year and the rehabilitation medicine complement to four residents per year. In addition, we will add a second orthopedic sports medicine fellow in the coming year.

When hand and upper extremity surgeon Neil Salyapongse, MD, joined our faculty in 2024, we gained an outstanding physician and academician – and a Vice Chair for Education. Here are a few of the new programs Dr. Salyapongse is spearheading:

Enhancement to our Simulation Education
A faculty workgroup has been assessing the modules available in our virtual reality platform to determine how best to educate early-year residents in surgical procedures ranging from arthroplasty to sports medicine to trauma. Using a select set of training modules, we hope to demonstrate earlier readiness for autonomy in the OR.

Orthopedics/Physical Medicine and Rehabilitation combined Grand Rounds
In keeping with the spirit of the Department as a cohesive whole, we are developing a series of department-wide Grand Rounds on topics that combine interests and expertise across both Orthopedic and Physical Medicine and Rehabilitation specialties. Nathan Rudin, MD, will lead off by sharing his expertise in hypermobility disorders.

Medical Student Education
The orthopedic clinical rotations have long been housed within the Department of Surgery due to our roots as a division of that department. We will formally assume responsibility for the rotations this coming year, allowing us to offer students a more uniform educational experience regardless of their subspecialty assignment.

A Commitment to Global Surgery

Continuing to demonstrate their longstanding commitment to excellent patient care across the global community, members of our orthopedic surgery team traveled to the far reaches of our world, performing surgery and providing training far beyond our borders:

Last year, Dr. Paul Whiting completed his fourth trip to Kenya, accompanied by orthopedic surgery residents Drs. Zachary French and Richard Behlmer. Their work was presented to the Department at a Grand Rounds session, detailing the broad impact of this visit on the education of surgeon colleagues in Kenya and our own participating residents. Dr. Kenneth Noonan returned this month, accompanied by Dr. French, for his (approximately) 15th visit to Honduras. Dr. Neil Salyapongse will return later this month for his fourth trip to Nepal, where he works alongside Orthopedic faculty at the only Hand Fellowship program in the country. He has had the pleasure of working with the fellowship since its inception and remains in frequent contact throughout the year with the graduates and faculty in the program. Our goal is to have a resident accompany him next cycle.

Advancing Gender Diversity in Orthopedic Surgery

The Department of Orthopedics and Rehabilitation at UW–Madison continues to address the long-standing gender imbalance in orthopedic surgery. Recognizing that women are historically underrepresented in the field, the Department has actively fostered an inclusive culture by mentoring female residents, faculty, and staff and prioritizing diversity in recruitment and leadership development.

In recent years, the Department has increased the proportion of female residents and faculty members, creating a more representative and supportive environment for women in orthopedics. We currently boast an orthopedic surgery faculty that is 25% female and an orthopedic residency cohort that is 30% female. Programs such as mentorship initiatives and professional development workshops have empowered our female clinicians and researchers to thrive in a traditionally male-dominated specialty. Additionally, the Department has partnered with organizations such as the Ruth Jackson Orthopaedic Society and Perry Initiative, which aim to inspire and support women pursuing careers in orthopedics.

By championing gender diversity, the Department is shaping a more equitable future for the field while enhancing the quality of care through diverse perspectives and experiences.

Philanthropy’s Impact on our Mission

Last fall, the Department reached a significant milestone when we successfully established the first-ever sports medicine endowed professorship, in honor of Dr. Bill Clancy, who founded our sports medicine program in the 1970s. This achievement, spurred by a matching opportunity from the Shapiro Foundation, demonstrates our unwavering commitment to advancing sports medicine education and research. Further, it is a testament to the support and passion of the many individuals who helped make this professorship a reality.

In 2025, we will continue to prioritize our mission. Led by Brandi Funk, our Advancement Manager, we intend to strengthen our Annual Fund for Orthopedic Innovation, which provides our Department with flexible and nimble funds needed for time-sensitive efforts and strategic and innovative collaborations. We’ll build upon our strong dedication to Education, with the fresh vision and leadership of our inaugural Vice Chair for Education, Dr. Neil Salyapongse. Finally, we intend to shine a bright light on Badger Athletic Performance Labs under the guidance of Dr. Bryan Heiderscheit. He and his team continue to thrive and connect with athletes, industry partners, researchers, and innovators here at home, nationally and internationally.

If you have any questions or thoughts about how you’d like to join us in these important development efforts with a philanthropic gift, please reach out directly to our Advancement Manager, Brandi Funk, funk@ortho.wisc.edu.


As we move into 2025, the momentum built over the past year positions us for even greater success. Our department continues to push the boundaries of clinical excellence, research innovation, education, and global impact. With the addition of talented faculty and groundbreaking research initiatives, we are well-equipped to meet the challenges ahead and to enhance patient care both locally and globally. Thank you to our dedicated faculty, staff, residents, and partners for your hard work and unwavering support – together, we will build on our legacy of excellence. I am excited for our future!